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ZW800-1 Forte, Carboxylic Acid

 

ZW800-1 Forte is a high-stability, zwitterionic, general-purpose NIR fluorophore with peak emission ≈ 700 nm for use with Channel #1 of the FLARE® imaging system. Because of its unique zwitterionic (i.e., geometrically-balanced and net-neutral poly-ionicity) chemical structure, ZW800-1 Forte exhibits extremely low non-specific binding and uptake both in vitro and in vivo, and also exhibits ≈ 100% renal clearance and elimination from the body into urine after a single intravenous injection. During the elimination process, ZW800-1 Forte highlights the ureters with an extremely high signal-to-background ratio for at least 60-90 minutes, making image-guided identification or avoidance of the ureters possible. ZW800-1 Forte, in conjunction with the FLARE® imaging system, permits extremely high resolution NIR fluorescence angiography of arteries, capillaries, and veins. Because of its single carboxylic acid and no other reactive groups, ZW800-1 Forte can also be used as a general-purpose labeling reagent, but is also available as a convenient reactive NHS ester or maleimide derivative for one-step conjugation. Forte fluorophores exhibit exceptionally high stability in warm serum. ZW800-1 Forte is a member of the Ligand-Match™ family of labeling reagents and can help solubilize poorly soluble molecules.

Specifications

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CHEMICAL PROPERTIES
Chemical Name Confidential
CAS Number N/A
Chemical Structure (2D/3D) N/A
Molecular Weight 1041 as a trifluoroacetate salt
Log D, pH 7.4 -2.80 (JChem Calculation)
Typical purity (@210 nm/@peak absorbance) ≥ 92%

 

PHYSICOCHEMICAL PROPERTIES
SOLVENT SOLUBILITY (Saturation Method)
     Water 6.5 mg/mL
     DMSO 8.5 mg/mL
FLARE® CHANNEL COMPABILITY
Channel #2 (≈ 800 nm NIR fluorescence)

 

OPTICAL PROPERTIES PBS, PH 7.4 DMSO 100% SERUM, PH 7.4
Excitation Max (nm) 685 / 754 778 685 /754
Emission Max (nm) 772 792 772
Stokes Shift (nm) 12 14 18
Extinction Coefficient (@ Ex max) 168,500 / 98,500 222,500 135,000 /115,000
Quantum Yield (%) – – –

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Copyright 2020 Curadel, LLC | All Rights Reserved
  • About us
    • History of FLARE®
    • Awards & Distinctions
  • FLARE®
    • Unique Features
    • Research Imaging Systems
    • Research Contrast Agents
    • Accessories
    • Services
    • Applications
  • Sales & Distribution
    • Distributors
    • Contact Curadel Sales
    • Leasing Options
  • Resource Sharing
    • Academic Metrics
    • Presentations
    • Publications
    • Request Research Reagents
    • Research Protocols
  • Contact Us
The Curadel Companies
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