Applications and Features

FLARE^® histology enables a standard H&E slide to be stained with two different NIR fluorescent secondary antibodies for perfect co-registration of biomarkers
FLARE^® and Histofluorescence Tomography™ (HFT): enables single cell resolution of multiple visible and NIR fluorescent biomarkers over the volume of an entire animal or large tissue. Compatible with virtually any standard microtome, cryotome, or macrotome
Real-time evaluation of drug effects on target tissues and organs:
- Both small and large animals
- 2-D perfusion imaging, targeted antibodies, and tissue-targeted agents
For drugs that can be tagged with a FLARE^® contrast agent, near single-cell resolution studies, and real-time imaging, in both small and large animals

FLARE^® cell tracking dyes will load any living cell within 30 to 60 minutes
700 nm and 800 nm NIR wavelengths are available. When combined with FLARE^® imaging systems, permits two-independent cell types to be tracked simultaneously, such as T-cells and tumor cells
Live animal tracking of cells in small and large animals with near-single cell resolution and millisecond temporal resolution. Follow cells accumulating at a site of interest from the time of injection
FLARE^® 3D Histofluorescence Tomography^® (HFT) permits localization of two different stem cell or immune cell populations over an entire small animal, tissue, or organ at near-single cell resolution. The MMC1 controller is compatible with any microtome, cryomicrotome, or cryomacrotome

Ultra-staging of lymph nodes at single cell resolution
High-sensitivity, high-specificity gross pathology preparation. Rapid identification of tumors, lymph nodes, or any other tissue type under real-time image guidance
FLARE^® histology permits a standard H&E slide to be stained with two different NIR fluorescent secondary antibodies for perfect co-registration of biomarkers
Histofluorescence tomography™ (HFT) permits single cell resolution of multiple visible and NIR fluorescent biomarkers over the volume of an entire animal or large tissue. Compatible with virtually any standard microtome, cryotome, or macrotome

Measure tissue regeneration and repair in real-time using gland- and tissue-specific FLARE^® contrast agents. Available contrast agents for cartilage, bone, thyroid, parathyroid, and adrenals
Confirm effective transplant of living tissue using real-time 2D perfusion mapping. Can be combined with any other biomarker for simultaneous imaging using FLARE^® imaging systems
Measure drug modulation of tissue transplant and tissue regeneration in real-time in living small and large animals
Evaluate tissue transplant and tissue regeneration at the near single-cell level using FLARE^® 3D Histofluorescence Tomography™ (HFT), or at true single cell level using FLARE^® histology and simultaneous H&E staining

Convert a Model RP1 or Model RP2 photonic control unit into a powerful PDT system capable of fluence rates as high as 200 mW/cm2 over a 1 cm2 area. Perfect for treatment of rodent tumors
Deliver high-fluence rate PDT at 445 nm, 520 nm, 665 nm, 760 nm, or combinations thereof
Combine the fluorescence quantum yield of PDT agents with a FLARE^® imaging system to image sensitizer distribution over the entire surface of a tumor or tissue in real-time before and after PDT treatment
Use the multi-channel capability of FLARE^® imaging systems to quantify 2-D tissue perfusion before and after PDT treatment in both small and large animals

Create new NIR fluorescent contrast agents for image-guided surgery using Curadel’s unique zwitterionic FLARE^® NIR fluorophores
Convert virtually any targeted small molecule, peptide, peptidomimetic, antibody, or other protein into a high sensitivity, high specificity contrast agent in one-step
Rapid measurement of blood-time curves using Curadel’s Cap-Trap™ capillary tube measurement system and only 15 µL of blood samples
Create new surgical procedures using NIR fluorescence guidance in both small and large animals with a state-of-the-art FLARE^® imaging system

Perform pre-clinical validation studies for new contrast agents and new surgical procedures in both small and large animals
Four simultaneous video streams, including two independent channels of NIR fluorescence, permits any combination of contrast agents to be used on any type of surgery
Minimally-invasive (including robotic) and open surgery systems are available
Dozens of contrast agents available for imaging of virtually any tissue, organ, or tumor in real-time, and with high sensitivity and high specificity
Sterile drapes and shields are available for experiments involving survival surgery

Curadel, LLC