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Applications and Features

Drug Discovery and Target Validation

  • FLARE® histology enables a standard H&E slide to be stained with two different NIR fluorescent secondary antibodies for perfect co-registration of biomarkers
  • FLARE® and Histofluorescence Tomography™ (HFT): enables single cell resolution of multiple visible and NIR fluorescent biomarkers over the volume of an entire animal or large tissue. Compatible with virtually any standard microtome, cryotome, or macrotome
  • Real-time evaluation of drug effects on target tissues and organs:
    • Both small and large animals
    • 2-D perfusion imaging, targeted antibodies, and tissue-targeted agents
  • For drugs that can be tagged with a FLARE® contrast agent, near single-cell resolution studies, and real-time imaging, in both small and large animals

Cell Tracking: Stem Cells, Immune Cells, and Malignant Cells

  • FLARE® cell tracking dyes will load any living cell within 30 to 60 minutes
  • 700 nm and 800 nm NIR wavelengths are available. When combined with FLARE® imaging systems, permits two-independent cell types to be tracked simultaneously, such as T-cells and tumor cells
  • Live animal tracking of cells in small and large animals with near-single cell resolution and millisecond temporal resolution. Follow cells accumulating at a site of interest from the time of injection
  • FLARE® 3D Histofluorescence Tomography® (HFT) permits localization of two different stem cell or immune cell populations over an entire small animal, tissue, or organ at near-single cell resolution. The MMC1 controller is compatible with any microtome, cryomicrotome, or cryomacrotome

Molecular Pathology

  • Ultra-staging of lymph nodes at single cell resolution
  • High-sensitivity, high-specificity gross pathology preparation. Rapid identification of tumors, lymph nodes, or any other tissue type under real-time image guidance
  • FLARE® histology permits a standard H&E slide to be stained with two different NIR fluorescent secondary antibodies for perfect co-registration of biomarkers
  • Histofluorescence tomography™ (HFT) permits single cell resolution of multiple visible and NIR fluorescent biomarkers over the volume of an entire animal or large tissue. Compatible with virtually any standard microtome, cryotome, or macrotome

Tissue Transplant and Tissue Regeneration

  • Measure tissue regeneration and repair in real-time using gland- and tissue-specific FLARE® contrast agents. Available contrast agents for cartilage, bone, thyroid, parathyroid, and adrenals
  • Confirm effective transplant of living tissue using real-time 2D perfusion mapping. Can be combined with any other biomarker for simultaneous imaging using FLARE® imaging systems
  • Measure drug modulation of tissue transplant and tissue regeneration in real-time in living small and large animals
  • Evaluate tissue transplant and tissue regeneration at the near single-cell level using FLARE® 3D Histofluorescence Tomography™ (HFT), or at true single cell level using FLARE® histology and simultaneous H&E staining

Photodynamic Therapy

  • Convert a Model RP1 or Model RP2 photonic control unit into a powerful PDT system capable of fluence rates as high as 200 mW/cm2 over a 1 cm2 area. Perfect for treatment of rodent tumors
  • Deliver high-fluence rate PDT at 445 nm, 520 nm, 665 nm, 760 nm, or combinations thereof
  • Combine the fluorescence quantum yield of PDT agents with a FLARE® imaging system to image sensitizer distribution over the entire surface of a tumor or tissue in real-time before and after PDT treatment
  • Use the multi-channel capability of FLARE® imaging systems to quantify 2-D tissue perfusion before and after PDT treatment in both small and large animals

New Contrast Agents for Image-Guided Surgery

  • Create new NIR fluorescent contrast agents for image-guided surgery using Curadel’s unique zwitterionic FLARE® NIR fluorophores
  • Convert virtually any targeted small molecule, peptide, peptidomimetic, antibody, or other protein into a high sensitivity, high specificity contrast agent in one-step
  • Rapid measurement of blood-time curves using Curadel’s Cap-Trap™ capillary tube measurement system and only 15 µL of blood samples
  • Create new surgical procedures using NIR fluorescence guidance in both small and large animals with a state-of-the-art FLARE® imaging system

Pre-Clinical Imaging of Small and Large Animals

  • Perform pre-clinical validation studies for new contrast agents and new surgical procedures in both small and large animals
  • Four simultaneous video streams, including two independent channels of NIR fluorescence, permits any combination of contrast agents to be used on any type of surgery
  • Minimally-invasive (including robotic) and open surgery systems are available
  • Dozens of contrast agents available for imaging of virtually any tissue, organ, or tumor in real-time, and with high sensitivity and high specificity
  • Sterile drapes and shields are available for experiments involving survival surgery

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T +1 508 305 2355
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Copyright 2020 Curadel, LLC | All Rights Reserved
  • About us
    • History of FLARE®
    • Awards & Distinctions
  • FLARE®
    • Unique Features
    • Research Imaging Systems
    • Research Contrast Agents
    • Accessories
    • Services
    • Applications
  • Sales & Distribution
    • Distributors
    • Contact Curadel Sales
    • Leasing Options
  • Resource Sharing
    • Academic Metrics
    • Presentations
    • Publications
    • Request Research Reagents
    • Research Protocols
  • Contact Us
The Curadel Companies