Lipo700 Forte, Carboxylic Acid
Lipo700 Forte is a high-stability, highly hydrophobic NIR fluorophore with peak emission ≈ 700 nm for use with Channel #1 of the FLARE® imaging system. Forte fluorophores exhibit exceptionally high stability in warm serum and because of its lipophilic and cationic structure, it penetrates cell membranes rapidly and can be used to label living cells, making identification and tracking possible both in vitro and in vivo. Depending on the cell type, and the presence of anionic transporters or efflux pumps, Lipo700 Forte can be retained for days within living cells, with cell division leading to dilution of the signal. Lipo700 Forte has a single carboxylic acid and no other reactive groups for chemical conjugation, but is also available as a convenient reactive NHS ester or maleimide derivative for one-step conjugation. Because of its chemical structure, Lipo700 Forte can facilitate the transport of other small molecules, including RNA and DNA, across cell membranes to the interior of the cell.
