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Lipo700 Forte, Carboxylic Acid

 

Lipo700 Forte is a high-stability, highly hydrophobic NIR fluorophore with peak emission ≈ 700 nm for use with Channel #1 of the FLARE® imaging system. Forte fluorophores exhibit exceptionally high stability in warm serum and because of its lipophilic and cationic structure, it penetrates cell membranes rapidly and can be used to label living cells, making identification and tracking possible both in vitro and in vivo. Depending on the cell type, and the presence of anionic transporters or efflux pumps, Lipo700 Forte can be retained for days within living cells, with cell division leading to dilution of the signal. Lipo700 Forte has a single carboxylic acid and no other reactive groups for chemical conjugation, but is also available as a convenient reactive NHS ester or maleimide derivative for one-step conjugation. Because of its chemical structure, Lipo700 Forte can facilitate the transport of other small molecules, including RNA and DNA, across cell membranes to the interior of the cell.

Specifications

  • Chemical
  • Optical
  • Documents
CHEMICAL PROPERTIES
Chemical Name Confidential
CAS Number N/A
Chemical Structure (2D/3D) Confidential
Molecular Weight 645 as trifluoroacetic salt
Log D, pH 7.4 5.93 (JChem Calculation)
Typical purity (@210 nm/@peak absorbance) ≥ 92%
PHYSICOCHEMICAL PROPERTIES
Ligand-Match™ Compatibility N/A (see reactive derivatives for labeling options)
SOLVENT SOLUBILITY (Super-Saturation Method)
PBS, pH 7.4 Insoluble (<0.007 mg/mL)
100% serum, pH 7.4 0.04 mg/mL (0.062 mM)
DMSO 68.7 mg/mL (107 mM)

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

FLARE® CHANNEL COMPABILITY
Channel #1 (≈ 700 nm NIR fluorescence)
OPTICAL PROPERTIES PBS, PH 7.4 100% SERUM, PH 7.4 DMSO
Excitation Max (nm) 640 649 646
Emission Max (nm) 666 671 668
Stokes Shift (nm) 26 22 22
Extinction Coefficient (@ Ex max) 138,500 131,500 139,500
Quantum Yield (%) – – –

Lipo700 Forte in FBS

Lipo700 Forte in DMSO

Lipo700 Forte in PBS

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

  • Product Brochure
  • Instructions for Use
  • Safety Data Sheet (Formerly MSDS)

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

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Copyright 2020 Curadel, LLC | All Rights Reserved
  • About us
    • History of FLARE®
    • Awards & Distinctions
  • FLARE®
    • Unique Features
    • Research Imaging Systems
    • Research Contrast Agents
    • Accessories
    • Services
    • Applications
  • Sales & Distribution
    • Distributors
    • Contact Curadel Sales
    • Leasing Options
  • Resource Sharing
    • Academic Metrics
    • Presentations
    • Publications
    • Request Research Reagents
    • Research Protocols
  • Contact Us
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