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ZW700-1 Forte, Carboxylic Acid

 

ZW700-1 Forte is a high-stability, zwitterionic, general-purpose NIR fluorophore with peak emission ≈ 700 nm for use with Channel #1 of the FLARE® imaging system. Because of its unique zwitterionic (i.e., geometrically-balanced and net-neutral poly-ionicity) chemical structure, ZW700-1 Forte exhibits extremely low non-specific binding and uptake both in vitro and in vivo, and also exhibits ≈ 100% renal clearance and elimination from the body into urine after a single intravenous injection. During the elimination process, ZW700-1 Forte highlights the ureters with an extremely high signal-to-background ratio for at least 60-90 minutes, making image-guided identification or avoidance of the ureters possible. After bolus intravenous injection, ZW700-1 Forte, in conjunction with the FLARE® imaging system, permits extremely high resolution NIR fluorescence angiography of arteries, capillaries, and veins. Because of its single carboxylic acid and no other reactive groups, ZW700-1 Forte can also be used as a general-purpose labeling reagent, but is also available as a convenient reactive NHS ester or maleimide derivative for one-step conjugation. Forte fluorophores exhibit exceptionally high stability in warm serum.

Specifications

  • Chemical
  • Optical
  • Documents
CHEMICAL PROPERTIES
Chemical Name Confidential
CAS Number Confidential
Chemical Structure (2D/3D) Confidential
Molecular Weight 975 as a trifluoroacetate salt
Log D, pH 7.4 -3.52 (JChem Calculation)
Typical purity (@210 nm/@peak absorbance) ≥ 92%
PHYSICOCHEMICAL PROPERTIES
Ligand-Match™ Compatibility N/A (see reactive derivatives for labeling options)
SOLVENT SOLUBILITY (Super-Saturation Method)
PBS, pH 7.4 2.5 mg/mL (2.6 mM)
100% serum, pH 7.4 2.6 mg/mL (2.7 mM)
DMSO 0.4 mg/mL (0.4 mM)
DMSO with acid 52 mg/mL (52 mM)

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

FLARE® CHANNEL COMPABILITY
Channel #1 (≈ 700 nm NIR fluorescence)
OPTICAL PROPERTIES PBS, PH 7.4 100% SERUM, PH 7.4 DMSO
Excitation Max (nm) 645 645 659
Emission Max (nm) 665 665 679
Stokes Shift (nm) 20 20 20
Extinction Coefficient (@ Ex max) 253,500 231,000 200,500
Quantum Yield (%)

ZW700-1 Forte in DMSO

ZW700-1 Forte in PBS

ZW700-1 Forte in FBS

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

  • Product Brochure
  • Instructions for Use
  • Safety Data Sheet (Formerly MSDS)

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

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Copyright 2020 Curadel, LLC | All Rights Reserved
  • About us
    • History of FLARE®
    • Awards & Distinctions
  • FLARE®
    • Unique Features
    • Research Imaging Systems
    • Research Contrast Agents
    • Accessories
    • Services
    • Applications
  • Sales & Distribution
    • Distributors
    • Contact Curadel Sales
    • Leasing Options
  • Resource Sharing
    • Academic Metrics
    • Presentations
    • Publications
    • Request Research Reagents
    • Research Protocols
  • Contact Us
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