ZW700-1 Forte, NHS Ester

ZW700-1 Forte-NHS is a high-stability, zwitterionic, general-purpose NIR fluorophore with peak emission ≈ 700 nm for use with Channel #1 of the FLARE^® imaging system. Equipped with a highly reactive N-hydroxysuccinimide (NHS) ester, ZW700-1 Forte-NHS can label virtually any small molecule, peptide, peptidomimetic, protein, antibody, or nanoparticle having a primary amine or other strong nucleophile, in a single-step reaction. Because of its “zwitterionic” chemical structure, it exhibits extremely low non-specific binding and uptake in vitro and in vivo, and can help solubilize poorly soluble targeting ligands. Once conjugated, Forte fluorophores exhibit exceptionally high stability in warm serum.

CHEMICAL PROPERTIES
Chemical Name	Confidential
CAS Number	N/A
Chemical Structure (2D/3D)	Confidential
Molecular Weight	1104 as a hexaflurophosphate salt
Log D, pH 7.4	-1.23(JChem Calculation)
Typical purity (@210 nm/@peak absorbance)	≥ 94%

PHYSICOCHEMICAL PROPERTIES
Ligand-Match™ Compatibility		N/A (see reactive derivatives for labeling options)
SOLVENT		SOLUBILITY (Super-Saturation Method)
	PBS, pH 7.4	0.28 mg/mL (0.25 mM)
	100% serum, pH 7.4	0.40 mg/mL (0.36 mM)
	DMSO	197 mg/mL (178 mM)

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

FLARE® CHANNEL COMPABILITY
Channel #1 (≈ 700 nm NIR fluorescence)

OPTICAL PROPERTIES	PBS, PH 7.4	100% SERUM, PH 7.4	DMSO
Excitation Max (nm)	645	645	659
Emission Max (nm)	665	665	679
Stokes Shift (nm)	20	20	20
Extinction Coefficient (@ Ex max)	253,500	231,000	200,500
Quantum Yield (%)

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

ZW700-1 Forte, NHS Ester

Specifications

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