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ZW700-1 Forte, NHS Ester

 

ZW700-1 Forte-NHS is a high-stability, zwitterionic, general-purpose NIR fluorophore with peak emission ≈ 700 nm for use with Channel #1 of the FLARE® imaging system. Equipped with a highly reactive N-hydroxysuccinimide (NHS) ester, ZW700-1 Forte-NHS can label virtually any small molecule, peptide, peptidomimetic, protein, antibody, or nanoparticle having a primary amine or other strong nucleophile, in a single-step reaction. Because of its “zwitterionic” chemical structure, it exhibits extremely low non-specific binding and uptake in vitro and in vivo, and can help solubilize poorly soluble targeting ligands. Once conjugated, Forte fluorophores exhibit exceptionally high stability in warm serum.

Specifications

  • Chemical
  • Optical
  • Documents
CHEMICAL PROPERTIES
Chemical Name Confidential
CAS Number N/A
Chemical Structure (2D/3D) Confidential
Molecular Weight 1104 as a hexaflurophosphate salt
Log D, pH 7.4 -1.23(JChem Calculation)
Typical purity (@210 nm/@peak absorbance) ≥ 94%
PHYSICOCHEMICAL PROPERTIES
Ligand-Match™ Compatibility N/A (see reactive derivatives for labeling options)
SOLVENT SOLUBILITY (Super-Saturation Method)
PBS, pH 7.4 0.28 mg/mL (0.25 mM)
100% serum, pH 7.4 0.40 mg/mL (0.36 mM)
DMSO 197 mg/mL (178 mM)

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

FLARE® CHANNEL COMPABILITY
Channel #1 (≈ 700 nm NIR fluorescence)
OPTICAL PROPERTIES PBS, PH 7.4 100% SERUM, PH 7.4 DMSO
Excitation Max (nm) 645 645 659
Emission Max (nm) 665 665 679
Stokes Shift (nm) 20 20 20
Extinction Coefficient (@ Ex max) 253,500 231,000 200,500
Quantum Yield (%)

ZW700-1 Forte in PBS copy

ZW700-1 Forte in FBS copy

ZW700-1 Forte in DMSO copy

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

  • Product Brochure
  • Instructions for Use
  • Safety Data Sheet (Formerly MSDS)

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

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  • About us
    • History of FLARE®
    • Awards & Distinctions
  • FLARE®
    • Unique Features
    • Research Imaging Systems
    • Research Contrast Agents
    • Accessories
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    • Applications
  • Sales & Distribution
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    • Contact Curadel Sales
    • Leasing Options
  • Resource Sharing
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  • Contact Us
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