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ZW800-1, Carboxylic Acid

 

ZW800-1 is the world’s first “zwitterionic” NIR fluorophore, having geometrically-balanced and net-neutral poly-ionicity. It is engineered with peak emission ≈ 800 nm for use with Channel #2 of the FLARE®imaging system. Because of this unique chemical structure, ZW800-1 exhibits extremely low non-specific binding and uptake both in vitro and in vivo, and also exhibits ≈ 100% renal clearance and elimination from the body into urine after a single intravenous injection. During the elimination process, ZW800-1 highlights the ureters with an extremely high signal-to-background ratio for at least 60-90 minutes, making image-guided identification or avoidance of the ureters possible. After bolus intravenous injection, ZW800-1, in conjunction with the FLARE® imaging system, permits extremely high resolution NIR fluorescence angiography of arteries, capillaries, and veins. Because of its single carboxylic acid and no other reactive groups, ZW800-1 can also be used as a general-purpose labeling reagent, but is also available as a convenient reactive NHS ester or maleimide derivative for one-step conjugation.

Specifications

  • Chemical
  • Optical
  • Documents
CHEMICAL PROPERTIES
Chemical Name 2-[(E)-2-[(3E)-2-[4-(2-carboxyethyl)phenoxy]-3-{2-[(2E)-3,3-dimethyl-5-sulfonato-1-[3-(trimethylazaniumyl)propyl]-2,3-dihydro-1H-indol-2-ylidene]ethylidene}cyclohex-1-en-1-yl]ethenyl]-3,3-dimethyl-1-[3-(trimethylazaniumyl)propyl]-3H-indol-1-ium-5-sulfonate trifluoroacetate
CAS Number 1239619-02-3 (Acid Form)
Chemical Structure (2D/3D) ZW800-1-CA PNG

Download ZW800-1CA ChemDraw File

Molecular Weight 1057.25 as trifluoroacetic salt
Log D, pH 7.4 -3.35 (JChem Calculation)
Typical purity (@210 nm/@peak absorbance) ≥ 95%
PHYSICOCHEMICAL PROPERTIES
Ligand-Match™ Compatibility Hydrophilic, 800 nm
SOLVENT SOLUBILITY (Super-Saturation Method)
PBS, pH 7.4 32.7 mg/mL (31 mM)
100% serum, pH 7.4 26.7 mg/mL (25.2 mM)
DMSO 2.9 mg/mL (2.8 mM)

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

FLARE® CHANNEL COMPABILITY
Channel #2 (≈ 800 nm NIR fluorescence)
OPTICAL PROPERTIES PBS, PH 7.4 100% SERUM, PH 7.4 DMSO
Excitation Max (nm) 768 770 792
Emission Max (nm) 786 788 808
Stokes Shift (nm) 18 18 16
Extinction Coefficient (@ Ex max) 235,000 254,000 251,000
Quantum Yield (%) 13.5 15.1 26.5

ZW800-1 in DMSO

ZW800-1 in PBS

ZW800-1 in FBS

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

  • Product Brochure
  • Instructions for Use
  • Safety Data Sheet (Formerly MSDS)

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

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  • About us
    • History of FLARE®
    • Awards & Distinctions
  • FLARE®
    • Unique Features
    • Research Imaging Systems
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  • Sales & Distribution
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