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ZW800-1 Forte, NHS Ester

 

ZW800-1 Forte-NHS is a zwitterionic, general-purpose NIR fluorophore with peak emission ≈ 800 nm for use with Channel #2 of the FLARE® imaging system. Equipped with a highly reactive N-hydroxysuccinimide (NHS) ester, ZW800-1-NHS can label virtually any small molecule, peptide, peptidomimetic, protein, antibody, or nanoparticle having a primary amine or other strong nucleophile, in a single-step reaction. Because of its “zwitterionic” chemical structure, it exhibits extremely low non-specific binding and uptake in vitro and in vivo, and can help solubilize poorly soluble targeting ligands. Because of its “zwitterionic” chemical structure, it exhibits extremely low non-specific binding and uptake in vitro and in vivo, and can help solubilize poorly soluble targeting ligands. Once conjugated, Forte fluorophores exhibit exceptionally high stability in warm serum.

Specifications

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CHEMICAL PROPERTIES
Chemical Name Confidential
CAS Number N/A
Chemical Structure (2D/3D) Confidential
Molecular Weight 1170 g/mol as a hexafluorophosphate salt
Log D, pH 7.4  -0.24 (JChem Calculation)
Typical purity (@210 nm/@peak absorbance)

 

≥ 95%

 

 

PHYSICOCHEMICAL PROPERTIES
SOLVENT SOLUBILITY (Saturation Method)
     PBS, pH 7.4 TBD
     100% Serum, pH 7.4 TBD
     DMSO TBD

Optical 

FLARE® CHANNEL COMPABILITY
Channel #2 (≈ 800 nm NIR fluorescence)

 

OPTICAL PROPERTIES PBS, PH 7.4 DMSO 100% SERUM, PH 7.4
Excitation Max (nm) 685 / 754 778 685 /754
Emission Max (nm) 772 792 772
Stokes Shift (nm) 12 14 18
Extinction Coefficient (@ Ex max) 168,500 / 98,500 222,500 135,000 /115,000
Quantum Yield (%) – – –

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  • About us
    • History of FLARE®
    • Awards & Distinctions
  • FLARE®
    • Unique Features
    • Research Imaging Systems
    • Research Contrast Agents
    • Accessories
    • Services
    • Applications
  • Sales & Distribution
    • Distributors
    • Contact Curadel Sales
    • Leasing Options
  • Resource Sharing
    • Academic Metrics
    • Presentations
    • Publications
    • Request Research Reagents
    • Research Protocols
  • Contact Us
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