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ZW800-1 Forte, TFP

 

ZW800-1 Forte-Tetrafluorphenyl (TFP) is a high-stability, zwitterionic, general-purpose NIR fluorophore with peak emission ≈ 800 nm for use with Channel #2 of the FLARE® imaging system. ZW800-1 Forte-TFP is an improvement over ZW800-1 Forte-NHS that allows for the same amide bond formation in a simple, one-step conjugation reaction with a much lower rate of hydrolysis in aqueous environments. This allows for more robust reaction conditions with less starting material being required to overcome hydrolysis to the unreactive carboxylic acid. Because of its “zwitterionic” chemical structure, it exhibits extremely low non-specific binding and uptake in vitro and in vivo, and can help solubilize poorly soluble targeting ligands. Once conjugated, Forte fluorophores exhibit exceptionally high stability in warm serum.

Specifications

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CHEMICAL PROPERTIES
Chemical Name Confidential
CAS Number N/A
Chemical Structure (2D/3D) Confidential
Molecular Weight 1189 g/mol as a trifluoroacetate salt
Log D, pH 7.4  2.77 (JChem Calculation)
Typical purity (@210 nm/@peak absorbance) ≥ 95%

 

PHYSICOCHEMICAL PROPERTIES
SOLVENT SOLUBILITY (Saturation Method)
     PBS, pH 7.4 TBD
     100% Serum, pH 7.4 TBD
     DMSO TBD
FLARE® CHANNEL COMPABILITY
Channel #2 (≈ 800 nm NIR fluorescence)

 

OPTICAL PROPERTIES PBS, PH 7.4 DMSO 100% SERUM, PH 7.4
Excitation Max (nm) 685 / 754 778 685 /754
Emission Max (nm) 772 792 772
Stokes Shift (nm) 12 14 18
Extinction Coefficient (@ Ex max) 168,500 / 98,500 222,500 135,000 /115,000
Quantum Yield (%) – – –
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  • About us
    • History of FLARE®
    • Awards & Distinctions
  • FLARE®
    • Unique Features
    • Research Imaging Systems
    • Research Contrast Agents
    • Accessories
    • Services
    • Applications
  • Sales & Distribution
    • Distributors
    • Contact Curadel Sales
    • Leasing Options
  • Resource Sharing
    • Academic Metrics
    • Presentations
    • Publications
    • Request Research Reagents
    • Research Protocols
  • Contact Us
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