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ZW800-1, NHS Ester

 

ZW800-1 NHS is a zwitterionic, general-purpose NIR fluorophore with peak emission ≈ 800 nm for use with Channel #2 of the FLARE® imaging system. Equipped with a highly reactive N-hydroxysuccinimide (NHS) ester, ZW800-1-NHS can label virtually any small molecule, peptide, peptidomimetic, protein, antibody, or nanoparticle having a primary amine or other strong nucleophile, in a single-step reaction. Because of its “zwitterionic” chemical structure, it exhibits extremely low non-specific binding and uptake in vitro and in vivo, and can help solubilize poorly soluble targeting ligands.

Specifications

  • Chemical
  • Optical
  • Documents
CHEMICAL PROPERTIES
Chemical Name 2-[(E)-2-[(3E)-3-{2-[(2E)-3,3-dimethyl-5-sulfonato-1-[3-(trimethylammonio)propyl]indol-2-ylidene]ethylidene}-2-(4-{3-[(2,5-dioxopyrrolidin-1-yl)oxy]-3-oxopropyl}phenoxy)cyclohex-1-en-1-yl]ethenyl]-3,3-dimethyl-1-[3-(trimethylammonio)propyl]indol-1-ium-5-sulfonate hexafluorophosphate
CAS Number 1360738-78-8
Chemical Structure (2D/3D) Chemical Structure ZW800-1 NHS
Molecular Weight 1186 as a hexafluorophosphate salt
Log D, pH 7.4 -0.62 (JChem Calculation)
Typical purity (@210 nm/@peak absorbance) ≥ 94%
PHYSICOCHEMICAL PROPERTIES
Ligand-Match™ Compatibility N/A
SOLVENT SOLUBILITY (Super-Saturation Method)
PBS, pH 7.4 9.0 mg/mL (7.6 mM)
100% serum, pH 7.4 N/A
DMSO 77.5 mg/mL (65.3 mM)

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

FLARE® CHANNEL COMPABILITY
Channel #2 (≈ 800 nm NIR fluorescence)
OPTICAL PROPERTIES PBS, PH 7.4 100% SERUM, PH 7.4 DMSO
Excitation Max (nm) 768 770 792
Emission Max (nm) 786 788 808
Stokes Shift (nm) 18 18 16
Extinction Coefficient (@ Ex max) 235,000 254,000 251,000
Quantum Yield (%) 13.5 15.1 26.5

ZW800-1 in PBS copy

ZW800-1 in FBS copy

ZW800-1 in DMSO copy

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

  • Product Brochure
  • Instructions for Use
  • Safety Data Sheet (Formerly MSDS)

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

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  • About us
    • History of FLARE®
    • Awards & Distinctions
  • FLARE®
    • Unique Features
    • Research Imaging Systems
    • Research Contrast Agents
    • Accessories
    • Services
    • Applications
  • Sales & Distribution
    • Distributors
    • Contact Curadel Sales
    • Leasing Options
  • Resource Sharing
    • Academic Metrics
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    • Request Research Reagents
    • Research Protocols
  • Contact Us
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