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ZW800-1, TFP

 

ZW800-1 Tetrafluorphenyl (TFP) is a high-stability, zwitterionic, general-purpose
NIR fluorophore with peak emission ≈ 700 nm for use with Channel #1 of the
FLARE® imaging system. ZW800-1 TFP is an improvement over ZW800-1 NHS that
allows for the same amide bond formation in a simple, one-step conjugation
reaction with a much lower rate of hydrolysis in aqueous environments. This allows
for more robust reaction conditions with less starting material being required to
overcome hydrolysis to the unreactive carboxylic acid. Because of its “zwitterionic”
chemical structure, it exhibits extremely low non-specific binding and uptake in
vitro and in vivo, and can help solubilize poorly soluble targeting ligands. Once
conjugated, Forte fluorophores exhibit exceptionally high stability in warm serum.

Specifications

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CHEMICAL PROPERTIES
Chemical Name Confidential
CAS Number N/A
Chemical Structure (2D/3D) Confidential
Molecular Weight 1205 g/mol as a trifluoroacetate salt
Log D, pH 7.4  2.38 (JChem Calculation)
Typical purity (@210 nm/@peak absorbance) ≥ 95%

 

PHYSICOCHEMICAL PROPERTIES
Ligand-Match™ Compatibility N/A
SOLVENT SOLUBILITY (Saturation Method)
     PBS, pH 7.4 TBD
     100% Serum, pH 7.4 TBD
     DMSO TBD
FLARE® CHANNEL COMPABILITY
Channel #2 (≈ 800 nm NIR fluorescence)
 

 

OPTICAL PROPERTIES PBS, PH 7.4 100% SERUM, PH 7.4 DMSO
Excitation Max (nm) 768 770 792
Emission Max (nm) 786 788 808
Stokes Shift (nm) 18 18 16
Extinction Coefficient (@ Ex max) 235,000 254,000 251,00
Quantum Yield (%) 13.5 15.1 26.5

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  • About us
    • History of FLARE®
    • Awards & Distinctions
  • FLARE®
    • Unique Features
    • Research Imaging Systems
    • Research Contrast Agents
    • Accessories
    • Services
    • Applications
  • Sales & Distribution
    • Distributors
    • Contact Curadel Sales
    • Leasing Options
  • Resource Sharing
    • Academic Metrics
    • Presentations
    • Publications
    • Request Research Reagents
    • Research Protocols
  • Contact Us
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